Blending

It depends on what your loads are. If you’re shooting max loads, I wouldn’t mix, and then just shoot one or two rounds across a chrono to make sure your loads are still in a safe range. If your loads aren’t at max, I wouldn’t worry about the different lot numbers.
 
I don't really mix powder's unless I've a bit left in one can and have to open a new one. Then I'll mix the two together. But having four different lots of the same powder, I work up a load with one lot and when it run's out simply take the next can regardless of lot # and go with the same load. But here's the thing, that's what I do and I'm not gonna guarantee your safety doing it! You need to decide what is best for you, as in what your willing to live with!
 
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